Article
Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery
2020-01-16
Abstract excerpt
<h4>ABSTRACT</h4> Successfully employing therapeutic nucleic acids, such as small interfering RNA (siRNA), requires chemical modifications or the use of nanocarrier technology to prevent their degradation in the circulation and to facilitate intracellular delivery. Lipid nanoparticles (LNP) are among the most advanced nanocarriers culminating in the first siRNA therapeutic’s clinical translation and approval. At...
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Identifiers and source
- Literature Corpus work
- a5c8169d-4b80-5878-8130-19feee3c9869
- DOI
- 10.1101/2020.01.16.907394