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⍺-Synuclein levels in Parkinson's disease – Cell types and forms that contribute to pathogenesis

14 Jul 2024

Abstract excerpt

Parkinson's disease (PD) has two main pathological hallmarks, the loss of nigral dopamine neurons and the proteinaceous aggregations of ⍺-synuclein (⍺Syn) in neuronal Lewy pathology. These two co-existing features suggest a causative association between ⍺Syn aggregation and the underpinning mechanism of neuronal degeneration in PD. Both increased levels and post-translational modifications of ⍺Syn can contribute...

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Neurological disorders and treatments
Nuclear Receptors and Signaling
Parkinson's Disease Mechanisms and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39009177
DOI: 10.1016/j.expneurol.2024.114887

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