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Article

The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder.

The international journal of neuropsychopharmacology - 1 Oct 2013

Lennertz Leonhard, Franke Petra E, Grabe Hans Jörgen, Rampacher Friederike, Schulze-Rauschenbach Svenja, Guttenthaler Vera, Ruhrmann Stephan, Pukrop Ralf, Klosterkötter Joachim, Falkai Peter, Maier Wolfgang, Wagner Michael, Mössner Rainald

Abstract excerpt

Neuropeptide S (NPS) is a novel central acting neuropeptide that modulates several brain functions. NPS has shown strong anxiolytic-like effects and interactions with other central transmitter systems, including serotonin and glutamate. A coding variation (Asn107Ile) of the NPS receptor gene (NPSR1) was associated with panic disorder and schizophrenia. Based on these encouraging findings, the present study aimed...

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Source

Identifiers

PMID: 23680103
DOI: 10.1017/S1461145713000382

Genes

NPSR1
NPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder.PMID 23680103Read ↗

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