Article
Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas.
Veterinary and comparative oncology - 1 Sept 2011
Murakami A, Mori T, Sakai H, Murakami M, Yanai T, Hoshino Y, Maruo K
Abstract excerpt
KIT, a transmembrane receptor tyrosine kinase, is one of the specific targets for anti-cancer therapy. In humans, its expression and mutations have been identified in malignant melanomas and therapies using molecular-targeted agents have been promising in these tumours. As human malignant melanoma, canine malignant melanoma is a fatal disease with metastases and the poor response has been observed with all...
Topics
- Animals
- DNA Mutational Analysis
- Dog Diseases
- Dogs
- Exons
- Gene Expression Regulation, Neoplastic
- Immunohistochemistry
- Melanoma
- Mouth Neoplasms
- Mutation
- Polymerase Chain Reaction