Article
Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma.
Cancer letters - 1 Jun 2000
Jeng Y M, Lin C Y, Hsu H C
Abstract excerpt
The c-Kit protein, a receptor type tyrosine kinase that plays an important role in the development of hematopoietic cells, melanocytes, and germ cells, is expressed in mastocytosis, gastrointestinal stromal cell tumors (GISTs), germ cell tumors, and several other tumors. Gain-of-function mutations in exon 11 and exon 17 have been shown as a mechanism of c-kit activation in some tumors. To study the role of c-kit...
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