Article
KIT gene exon 11 mutations in canine malignant melanoma.
Veterinary journal (London, England : 1997) - 1 May 2013
Chu Pei-Yi, Pan Siou-Li, Liu Chen-Hsuan, Lee Jihjong, Yeh Lih-Seng, Liao Albert T
Abstract excerpt
The proto-oncogene KIT encodes a receptor tyrosine kinase which has been shown to be upregulated in canine melanomas. KIT mutations lead to constitutive phosphorylation and activation of KIT in the absence of ligand binding. The presence of KIT mutations and KIT protein expression was examined in a cohort of 49 dogs with canine malignant melanoma. An exon 11 synonymous nucleotide 1743C→T mutation was identified...
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