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Article

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.

Human molecular genetics - 15 Dec 2001

Esteller M, Fraga M F, Guo M, Garcia-Foncillas J, Hedenfalk I, Godwin A K, Trojan J, Vaurs-Barrière C, Bignon Y J, Ramus S, Benitez J, Caldes T, Akiyama Y, Yuasa Y, Launonen V, Canal M J, Rodriguez R, Capella G, Peinado M A, Borg A, Aaltonen L A, Ponder B A, Baylin S B, Herman J G

Abstract excerpt

Cancer cells have aberrant patterns of DNA methylation including hypermethylation of gene promoter CpG islands and global demethylation of the genome. Genes that cause familial cancer, as well as other genes, can be silenced by promoter hypermethylation in sporadic tumors, but the methylation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11751682
DOI: 10.1093/hmg/10.26.3001

Genes

APC
BRCA1
CDH1
GSTP1
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11751682-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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