Article
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.
Human molecular genetics - 15 Dec 2001
Esteller M, Fraga M F, Guo M, Garcia-Foncillas J, Hedenfalk I, Godwin A K, Trojan J, Vaurs-Barrière C, Bignon Y J, Ramus S, Benitez J, Caldes T, Akiyama Y, Yuasa Y, Launonen V, Canal M J, Rodriguez R, Capella G, Peinado M A, Borg A, Aaltonen L A, Ponder B A, Baylin S B, Herman J G
Abstract excerpt
Cancer cells have aberrant patterns of DNA methylation including hypermethylation of gene promoter CpG islands and global demethylation of the genome. Genes that cause familial cancer, as well as other genes, can be silenced by promoter hypermethylation in sporadic tumors, but the methylation of these genes in tumors from kindreds with inherited cancer syndromes has not been well characterized. Here, we examine...
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