The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo.

doi:10.1016/j.meegid.2015.08.031

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Article

The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2015

Zhao Hui, Du Yanli, Chen Shunmei, Qing Lili, Wang Xiaoyan, Huang Jingfei, Wu Dongdong, Zhang Yaping

Abstract excerpt

Prion protein, encoded by the prion protein gene (PRNP), plays a crucial role in the pathogenesis of transmissible spongiform encephalopathies (TSEs). Several polymorphisms within the PRNP are known to be associated with influencing bovine spongiform encephalopathy (BSE) susceptibility in cattle, namely two insertion/deletion (indel) polymorphisms (a 23-bp indel in the putative promoter and a 12-bp indel in...

Topics

Alleles
Amino Acid Substitution
Animals
Buffaloes
Cattle
Disease Susceptibility
Encephalopathy, Bovine Spongiform
Evolution, Molecular
Gene Frequency
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

INDEL Mutation

Open Reading Frames

Phylogeny

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Prions

Tandem Repeat Sequences

Source

Open in PubMed

Identifiers

PMID: 26319996
DOI: 10.1016/j.meegid.2015.08.031

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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