Article
Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers.
PLoS genetics - 1 Dec 2014
Taylor Amy E, Morris Richard W, Fluharty Meg E, Bjorngaard Johan H, Åsvold Bjørn Olav, Gabrielsen Maiken E, Campbell Archie, Marioni Riccardo, Kumari Meena, Hällfors Jenni, Männistö Satu, Marques-Vidal Pedro, Kaakinen Marika, Cavadino Alana, Postmus Iris, Husemoen Lise Lotte N, Skaaby Tea, Ahluwalia Tarunveer S, Treur Jorien L, Willemsen Gonneke, Dale Caroline, Wannamethee S Goya, Lahti Jari, Palotie Aarno, Räikkönen Katri, Kisialiou Aliaksei, McConnachie Alex, Padmanabhan Sandosh, Wong Andrew, Dalgård Christine, Paternoster Lavinia, Ben-Shlomo Yoav, Tyrrell Jessica, Horwood John, Fergusson David M, Kennedy Martin A, Frayling Tim, Nohr Ellen A, Christiansen Lene, Ohm Kyvik Kirsten, Kuh Diana, Watt Graham, Eriksson Johan, Whincup Peter H, Vink Jacqueline M, Boomsma Dorret I, Davey Smith George, Lawlor Debbie, Linneberg Allan, Ford Ian, Jukema J Wouter, Power Christine, Hyppönen Elina, Jarvelin Marjo-Riitta, Preisig Martin, Borodulin Katja, Kaprio Jaakko, Kivimaki Mika, Smith Blair H, Hayward Caroline, Romundstad Pål R, Sørensen Thorkild I A, Munafò Marcus R, Sattar Naveed
Abstract excerpt
We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in...
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