Article
Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index.
International journal of epidemiology - 1 Dec 2011
Freathy Rachel M, Kazeem Gbenga R, Morris Richard W, Johnson Paul C D, Paternoster Lavinia, Ebrahim Shah, Hattersley Andrew T, Hill Anita, Hingorani Aroon D, Holst Claus, Jefferis Barbara J, Kring Sofia I I, Mooser Vincent, Padmanabhan Sandosh, Preisig Martin, Ring Susan M, Sattar Naveed, Upton Mark N, Vollenweider Peter, Waeber Gerard, Sørensen Thorkild I A, Frayling Timothy M, Watt Graham, Lawlor Debbie A, Whincup Peter H, Tozzi Federica, Davey Smith George, Munafò Marcus
Abstract excerpt
BACKGROUND: Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking...
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