Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints.

DNA repair - 2 Jan 2012

Becerra Sandra C, Thambugala Hiranthi T, Erickson Alison Russell, Lee Christopher K, Lewis L Kevin

Abstract excerpt

Primary human somatic cells grown in culture divide a finite number of times, exhibiting progressive changes in metabolism and morphology before cessation of cycling. This telomere-initiated cellular senescence occurs because cells have halted production of telomerase, a DNA polymerase required for stabilization of chromosome ends. Telomerase-deficient Saccharomyces cerevisiae cells undergo a similar process,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Checkpoints
Share to Chromosomes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colony Count, Microbial

Share to Homologous Recombination

Share to Microbial Viability

Share to Saccharomyces cerevisiae

Share to Telomerase

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 22071150
DOI: 10.1016/j.dnarep.2011.10.003
PMCID: PMC3253946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints.PMID 22071150Read ↗

Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere ShorteningSemantic proximity Read ↗

Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.Semantic proximity Read ↗

Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.Semantic proximity Read ↗

Replication stress as a source of telomere recombination during replicative senescence inSaccharomyces cerevisiaeSemantic proximity Read ↗

Senescence and immortalization: role of telomeres and telomeraseSemantic proximity Read ↗

Telomere-Telomere Recombination Is an Efficient Bypass Pathway for Telomere Maintenance in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Human embryonic stem cells: mechanisms to escape replicative senescence?Semantic proximity Read ↗

Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiae.Semantic proximity Read ↗

Reversible Manipulation of Telomerase Expression and Telomere LengthSemantic proximity Read ↗

Extension of life-span by introduction of telomerase into normal human cells.Semantic proximity Read ↗

Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblastsSemantic proximity Read ↗

Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.