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Article

Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts

3 Sept 2019

Abstract excerpt

Significance In the classic view, telomerase is silenced in terminally differentiated cells and its reactivation supports immortalization and unlimited growth of most cancers. Here, we determine the involvement of telomerase during replicative senescence in primary fibroblasts from mouse and human. In both cases, we find that cells that are unable to produce telomerase approach cellular senescence earlier and...

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PMID: 31481614
DOI: 10.1073/pnas.1907199116

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