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Article

A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction.

Cardiovascular research - 1 Aug 2011

Jung Carole, Gené Gemma G, Tomás Marta, Plata Cristina, Selent Jana, Pastor Manuel, Fandos César, Senti Mariano, Lucas Gavin, Elosua Roberto, Valverde Miguel A

Abstract excerpt

AIMS: The TRPC4 non-selective cation channel is widely expressed in the endothelium, where it generates Ca(2+) signals that participate in the endothelium-mediated vasodilatory response. This study sought to identify single-nucleotide polymorphisms (SNPs) in the TRPC4 gene that are associated with myocardial infarction (MI). METHODS AND RESULTS: Our candidate-gene association studies identified a missense SNP...

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Source

Identifiers

PMID: 21427121
DOI: 10.1093/cvr/cvr083

Genes

TRPC4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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