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Article

P2X7 receptor polymorphisms do not influence endothelial function and vascular tone in neo-diagnosed, treatment-naive essential hypertensive patients.

Journal of hypertension - 1 Dec 2013

Ghiadoni Lorenzo, Rossi Chiara, Duranti Emiliano, Santini Eleonora, Bruno Rosa Maria, Salvati Antonio, Taddei Stefano, Solini Anna

Abstract excerpt

OBJECTIVE: Endothelial dysfunction and arterial stiffness are early vascular alterations, linked to oxidative stress and inflammation, with prognostic significance in essential hypertensive patients. P2X7 receptors (P2X7R), responding to extracellular ATP, are encoded by a highly polymorphic gene and modulate inflammatory responses and cell growth, potentially playing a role in the control of vascular tone. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Purinergic P2X7

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Identifiers

PMID: 24220590
DOI: 10.1097/HJH.0b013e3283653ff5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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