Article
RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations.
Molecular cell - 1 Mar 2001
Luo X, Popov S, Bera A K, Wilkie T M, Muallem S
Abstract excerpt
Agonist-evoked [Ca2+]i oscillations have been considered a biophysical phenomenon reflecting the regulation of the IP3 receptor by [Ca2+]i. Here we show that [Ca2+]i oscillations are a biochemical phenomenon emanating from regulation of Ca2+ signaling by the regulators of G protein signaling (RGS) proteins. [Ca2+]i oscillations evoked by G protein-coupled receptors require the action of RGS proteins. Inhibition...
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