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Article

RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003

Tosetti Patrizia, Pathak Narendra, Jacob Michele H, Dunlap Kathleen

Abstract excerpt

G proteins modulate synaptic transmission. Regulators of G protein signaling (RGS) proteins accelerate the intrinsic GTPase activity of Galpha subunits, and thus terminate G protein activation. Whether RGS proteins themselves are under cellular control is not well defined, particularly in native cells. In dorsal root ganglion neurons overexpressing RGS3, we find that G protein signaling is rapidly terminated (or...

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Identifiers

PMID: 12771384
DOI: 10.1073/pnas.1231837100
PMCID: PMC165876

Genes

RGS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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