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Article

Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channels.

The Journal of general physiology - 1 Jan 1999

Melliti K, Meza U, Fisher R, Adams B

Abstract excerpt

Regulators of G protein signaling (RGS) proteins bind to the alpha subunits of certain heterotrimeric G proteins and greatly enhance their rate of GTP hydrolysis, thereby determining the time course of interactions among Galpha, Gbetagamma, and their effectors. Voltage-gated N-type Ca channels mediate neurosecretion, and these Ca channels are powerfully inhibited by G proteins. To determine whether RGS proteins...

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Identifiers

PMID: 9874691
DOI: 10.1085/jgp.113.1.97
PMCID: PMC2222986

Genes

RGS8
RGS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channels.PMID 9874691Read ↗

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Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases.Semantic proximity Read ↗

GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.Semantic proximity Read ↗

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