Article
HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension.
Scientific reports - 16 Jul 2020
Almodovar Sharilyn, Wade Brandy E, Porter Kristi M, Smith Justin M, Lopez-Astacio Robert A, Bijli Kaiser, Kang Bum-Yong, Cribbs Sushma K, Guidot David M, Molehin Deborah, McNair Bryan K, Pumarejo-Gomez Laura, Perez Hernandez Jaritza, Salazar Ethan A, Martinez Edgar G, Huang Laurence, Kessing Cari F, Suarez-Martinez Edu B, Pruitt Kevin, Hsue Priscilla Y, Tyor William R, Flores Sonia C, Sutliff Roy L
Abstract excerpt
Pulmonary Arterial Hypertension (PAH) is overrepresented in People Living with Human Immunodeficiency Virus (PLWH). HIV protein gp120 plays a key role in the pathogenesis of HIV-PAH. Genetic changes in HIV gp120 determine viral interactions with chemokine receptors; specifically, HIV-X4 viruses interact with CXCR4 while HIV-R5 interact with CCR5 co-receptors. Herein, we leveraged banked samples from patients...
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