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Article

Effects of RNAi-mediated knockdown of <i>Xist</i> on the developmental efficiency of cloned male porcine embryos

1 Jan 2016

Abstract excerpt

Xist is an X-linked gene responsible for cis induction of X chromosome inactivation. Studies have indicated that Xist is abnormally activated in the active X chromosome in cloned mouse embryos due to loss of the maternal Xist-repressing imprint following enucleation during somatic cell nuclear transfer (SCNT). Inhibition of Xist expression by injecting small interfering RNA (siRNA) has been shown to enhance the...

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PMID: 27569767
DOI: 10.1262/jrd.2016-095

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