Article
Mutation of the XIST gene upregulates expression of X-linked genes but decreases the developmental rates of cloned male porcine embryos.
Molecular reproduction and development - 1 Jun 2017
Yang Yang, Wu Dan, Liu Dewu, Shi Junsong, Zhou Rong, He Xiaoyan, Quan Jianping, Cai Gengyuan, Zheng Enqin, Wu Zhenfang, Li Zicong
Abstract excerpt
XIST is an X-linked, non-coding gene responsible for the cis induction of X-chromosome inactivation (XCI). Knockout of the XIST allele on an active X chromosome abolishes erroneous XCI and enhances the in vivo development of cloned mouse embryos by more than 10-fold. This study aimed to investigate whether a similar manipulation would improve cloning efficiency in pigs. A male, porcine kidney cell line containing...
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