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Article

The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.

International journal of colorectal disease - 1 May 2012

Prager Matthias, Büttner Janine, Haas Verena, Baumgart Daniel C, Sturm Andreas, Zeitz Martin, Büning Carsten

Abstract excerpt

PURPOSE: The aetiology of intestinal barrier dysfunction in Crohn's disease (CD) is poorly understood. Associations in relatives of CD families suggest a genetic basis, but the relevant variants are still unknown. We hypothesized that variants in genes occurring in pathways such as autophagy and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22065112
DOI: 10.1007/s00384-011-1345-y

Genes

JAK2
STAT3
IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22065112-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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