Article
Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population.
Mutation research - 7 Aug 2010
Ferguson Lynnette R, Han Dug Yeo, Fraser Alan G, Huebner Claudia, Lam Wen Jiun, Morgan Angharad R, Duan He, Karunasinghe Nishi
Abstract excerpt
The Signal Transducers and Activators of Transcription (STAT)-Janus kinase (JAK) pathway controls signal transduction between cell surface receptors and the nucleus. Two members of that pathway, STAT3 and JAK2, enhanced the risk of Crohn's disease (CD) in recent genome-wide association studies. We replicated these findings in a New Zealand Caucasian case-control cohort, by genotyping two single nucleotide...
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