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Increased small intestinal permeability in ulcerative colitis: rather genetic than environmental and a risk factor for extensive disease?

Inflammatory bowel diseases - 1 Oct 2012

Büning Carsten, Geissler Nora, Prager Matthias, Sturm Andreas, Baumgart Daniel C, Büttner Janine, Bühner Sabine, Haas Verena, Lochs Herbert

Abstract excerpt

BACKGROUND: A disturbed epithelial barrier could play a pivotal role in ulcerative colitis (UC). We performed a family-based study analyzing in vivo gastrointestinal permeability in patients with UC, their healthy relatives, spouses, and controls. METHODS: In total, 89 patients with UC in remission, 35 first-degree relatives (UC-R), 24 nonrelated spouses (UC-NR), and 99 healthy controls (HC) were studied....

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PMID: 22344959
DOI: 10.1002/ibd.22909

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