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A single nucleotide polymorphism in the STAT5 gene favors colonic as opposed to small-bowel inflammation in Crohn's disease.

Diseases of the colon and rectum - 1 Sept 2013

Connelly Tara M, Koltun Walter A, Berg Arthur S, Hegarty John P, Brinton David, Deiling Sue, Poritz Lisa S, Stewart David B

Abstract excerpt

BACKGROUND: Crohn's disease is a chronic inflammatory ailment that can affect the colon and/or small intestine. A genetic basis for disease distribution is being sought, although the available data are seminal. The STAT5 gene is known to influence colonic permeability, mucosal regeneration, and interleukin 2 production, although its role in the distribution of Crohn's disease is unclear. OBJECTIVE: The aim of...

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PMID: 23929016
DOI: 10.1097/DCR.0b013e31829de128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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