A single nucleotide polymorphism in the STAT5 gene favors colonic as opposed to small-bowel inflammation in Crohn's disease.

doi:10.1097/DCR.0b013e31829de128

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Article

A single nucleotide polymorphism in the STAT5 gene favors colonic as opposed to small-bowel inflammation in Crohn's disease.

Diseases of the colon and rectum - 1 Sept 2013

Connelly Tara M, Koltun Walter A, Berg Arthur S, Hegarty John P, Brinton David, Deiling Sue, Poritz Lisa S, Stewart David B

Abstract excerpt

BACKGROUND: Crohn's disease is a chronic inflammatory ailment that can affect the colon and/or small intestine. A genetic basis for disease distribution is being sought, although the available data are seminal. The STAT5 gene is known to influence colonic permeability, mucosal regeneration, and interleukin 2 production, although its role in the distribution of Crohn's disease is unclear. OBJECTIVE: The aim of...

Topics

Adolescent
Adult
Cohort Studies
Colitis
Crohn Disease
Female
Genetic Markers
Genotype
Genotyping Techniques
Humans
Ileitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Logistic Models

Male

Polymorphism, Single Nucleotide

Retrospective Studies

STAT5 Transcription Factor

Young Adult

Source

Open in PubMed

Identifiers

PMID: 23929016
DOI: 10.1097/DCR.0b013e31829de128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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