Article
Linkage and association analyses of glaucoma related traits in a large pedigree from a Dutch genetically isolated population.
Journal of medical genetics - 1 Dec 2011
Axenovich Tatiana, Zorkoltseva Irina, Belonogova Nadezhda, van Koolwijk Leonike M E, van Koolwijk Leonike, Borodin Pavel, Kirichenko Anatoly, Babenko Vladimir, Ramdas Wishal D, Ramdas Wishal, Amin Najaf, Despriet Dominiec D G, Despriet Dominiec, Vingerling Johannes R, Vingerling Johannes, Lemij Hans G, Lemij Hans, Oostra B A, Klaver Caroline C W, Klaver Caroline, Aulchenko Yurii S, Aulchenko Yurii, van Duijn Cornelia M, van Duijn Cornelia
Abstract excerpt
BACKGROUND: Despite extensive research on the genetic determinants of glaucoma, the genes identified to date explain only a small proportion of cases in the general population. METHODS: Genome-wide linkage and association analyses of quantitative traits related to glaucoma were performed: intraocular pressure, size and morphology of the optic disc (individual and combined by method of principal components) and...
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