Article
A genetic epidemiologic study of candidate genes involved in the optic nerve head morphology.
Investigative ophthalmology & visual science - 21 Mar 2012
Gasten Andrea C, Ramdas Wishal D, Broer Linda, van Koolwijk Leonieke M E, Ikram M Kamran, de Jong Paulus T V M, Aulchenko Yurii S, Wolfs Roger C, Hofman Albert, Rivadeneira Fernando, Uitterlinden Andre G, Oostra Ben A, Lemij Hans G, Klaver Caroline C W, Jansonius Nomdo M, Vingerling Johannes R, van Duijn Cornelia M
Abstract excerpt
PURPOSE: The size of the optic nerve head, referred to as disc area (DA), and the vertical cup-disc ratio (VCDR), are clinically relevant parameters for glaucomatous optic neuropathy. Although these measures have a high heritability, little is known about the underlying genes. Previously, the genes SALL1 and SIX1 were found to be genome-wide significantly associated with DA and VCDR. The purpose of the present...
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