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Article

A Common Glaucoma-risk Variant of SIX6 Alters Retinal Nerve Fiber Layer and Optic Disc Measures in a European Population: The EPIC-Norfolk Eye Study.

Journal of glaucoma - 1 Sept 2018

Khawaja Anthony P, Chan Michelle P Y, Yip Jennifer L Y, Broadway David C, Garway-Heath David F, Viswanathan Ananth C, Luben Robert, Hayat Shabina, Hauser Michael A, Wareham Nicholas J, Khaw Kay-Tee, Fortune Brad, Allingham R Rand, Foster Paul J

Abstract excerpt

PURPOSE: A common missense variant in the SIX6 gene (rs33912345) is strongly associated with primary open-angle glaucoma (POAG). We aimed to examine the association of rs33912345 with optic disc and retinal nerve fiber layer (RNFL) measures in a European population. METHODS: We examined participants of the population-based EPIC-Norfolk Eye Study. Participants underwent confocal laser scanning tomography...

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Identifiers

PMID: 30005032
DOI: 10.1097/IJG.0000000000001026
PMCID: PMC6119604

Genes

SIX6

Provenance

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