Article
Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination.
Glia - 1 Feb 2012
Velanac Viktorija, Unterbarnscheidt Tilmann, Hinrichs Wilko, Gummert Maike N, Fischer Tobias M, Rossner Moritz J, Trimarco Amelia, Brivio Veronica, Taveggia Carla, Willem Michael, Haass Christian, Möbius Wiebke, Nave Klaus-Armin, Schwab Markus H
Abstract excerpt
Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous system, neuregulin 1 (NRG1) type III is a key regulator of this process. It has been proposed that the protease BACE1 activates NRG1 dependent myelination. Here, we characterize the predicted product of BACE1-mediated NRG1 type III processing in transgenic mice. Neuronal overexpression of a NRG1 type III-variant, designed...
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