Article

Enhanced axonal Neuregulin-1 type-III signaling ameliorates disease severity in a CMT1B mouse model

2018-08-07

Abstract excerpt

<h4>ABSTRACT</h4> Charcot–Marie–Tooth neuropathies (CMTs) are a group of genetic disorders that affect the peripheral nervous system (PNS) with heterogeneous pathogenesis and no available treatment. Axonal Neuregulin 1 type III (Nrg1TIII) drives peripheral nerve myelination by activating downstream signaling pathways such as PI3K/Akt and MAPK/Erk that converge on master transcriptional regulators of myelin genes,...

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Literature Corpus work: a0adbf3f-79f2-523b-acae-4cbdbfa7ccbb
DOI: 10.1101/386730

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