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Article

Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2013

Hu Xiangyou, Schlanger Rita, He Wanxia, Macklin Wendy B, Yan Riqiang

Abstract excerpt

β-Site amyloid precursor protein convertase enzyme 1 (BACE1), a type I transmembrane aspartyl protease required to cleave amyloid precursor protein for releasing a toxic amyloid peptide, also cleaves type I and type III neuregulin-1 (Nrg-1). BACE1 deficiency in mice causes hypomyelination during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23335052
DOI: 10.1096/fj.12-224212
PMCID: PMC3633823

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23335052-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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