High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.

doi:10.1074/jbc.M111.275990

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Article

High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.

The Journal of biological chemistry - 6 Jan 2012

Zhang Li, Lim Siok Lam, Du Hongjun, Zhang Ming, Kozak Igor, Hannum Gregory, Wang Xiaolei, Ouyang Hong, Hughes Guy, Zhao Ling, Zhu Xuemei, Lee Clara, Su Zhiguang, Zhou Xinrong, Shaw Robert, Geum Dongho, Wei Xinran, Zhu Jin, Ideker Trey, Oka Chio, Wang Ningli, Yang Zhenglin, Shaw Peter X, Zhang Kang

Abstract excerpt

Genome-wide association study (GWAS) has identified genetic variants in the promoter region of the high temperature requirement factor A1 (HTRA1) gene associated with age-related macular degeneration (AMD). As a secreted serine protease, HTRA1 has been reported to interact with members of the transforming growth factor-β (TGF-β) family and regulate their signaling pathways. Growth differentiation factor 6 (GDF6),...

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Identifiers

PMID: 22049084
DOI: 10.1074/jbc.M111.275990
PMCID: PMC3256864

Genes

GDF6
HTRA1
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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