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Article

Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs.

PloS one - 1 Jan 2012

Jiang Jingjing, Huang Lvzhen, Yu Wenzhen, Wu Xi, Zhou Peng, Li Xiaoxin

Abstract excerpt

Multiple genetic studies have suggested that high-temperature requirement serine protease (HTRA1) is associated with polypoidal choroidal vasculopathy (PCV). To date, no functional studies have investigated the biological effect of HTRA1 on vascular endothelial cells, essential vascular components involved in polypoidal vascular abnormalities and arteriosclerosis-like changes. In vitro studies were performed to...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23056244
DOI: 10.1371/journal.pone.0046115
PMCID: PMC3466263

Genes

HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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