Codon usage in mitochondrial genomes: distinguishing context-dependent mutation from translational selection.

doi:10.1093/molbev/msm259

Back to search

Article

Codon usage in mitochondrial genomes: distinguishing context-dependent mutation from translational selection.

Molecular biology and evolution - 1 Feb 2008

Jia Wenli, Higgs Paul G

Abstract excerpt

We analyze the frequencies of synonymous codons in animal mitochondrial genomes, focusing particularly on mammals and fish. The frequencies of bases at 4-fold degenerate sites are found to be strongly influenced by context-dependent mutation, which causes correlations between pairs of neighboring...

Topics

Animals
Codon
Evolution, Molecular
Genetic Code
Genetic Variation
Genome, Mitochondrial
Mutation
Open Reading Frames

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.