Article
Two steps of insulin receptor internalization depend on different domains of the beta-subunit.
The Journal of cell biology - 1 Sept 1993
Carpentier J L, Paccaud J P, Backer J, Gilbert A, Orci L, Kahn C R, Baecker J [corrected to Backer J ]
Abstract excerpt
The internalization of signaling receptors such as the insulin receptor is a complex, multi-step process. The aim of the present work was to determine the various steps in internalization of the insulin receptor and to establish which receptor domains are implicated in each of these by the use of receptors possessing in vitro mutations. We find that kinase activation and autophosphorylation of all three...
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