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Article

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2011

Michels Aaron W, Ostrov David A, Zhang Li, Nakayama Maki, Fuse Masanori, McDaniel Kristen, Roep Bart O, Gottlieb Peter A, Atkinson Mark A, Eisenbarth George S

Abstract excerpt

Class II major histocompatibility molecules are the primary susceptibility locus for many autoimmune disorders, including type 1 diabetes. Human DQ8 and I-A(g7), in the NOD mouse model of spontaneous autoimmune diabetes, confers diabetes risk by modulating presentation of specific islet peptides in the thymus and periphery. We used an in silico molecular docking program to screen a large "druglike" chemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22043012
DOI: 10.4049/jimmunol.1100746
PMCID: PMC3221928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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