Article
Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990
Kumar V, Urban J L, Horvath S J, Hood L
Abstract excerpt
Myelin basic protein (MBP) or helper T cells reactive against MBP induce an autoimmune disease, experimental allergic encephalomyelitis, in B10.PL and PL/J inbred mice. In both strains, virtually the entire repertoire of MBP-specific T cells recognize an N-terminal peptide fragment in the context of the I-Au molecule encoded by the major histocompatibility complex (MHC) and utilize a very limited set of T-cell...
Topics
- Amino Acid Sequence
- Animals
- Binding, Competitive
- DNA Replication
- Encephalomyelitis, Autoimmune, Experimental
- Interleukin-2
- Kinetics
- Lymph Nodes
- Lymphocyte Activation
- Major Histocompatibility Complex