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Article

Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model.

Frontiers in immunology - 1 Jan 2021

Li Cheuk Wun, Osman Roman, Menconi Francesca, Faustino Larissa C, Kim Kookjoo, Clarke Oliver B, Hou Hanxi, Tomer Yaron

Abstract excerpt

Autoimmune polyglandular syndrome type 3 variant (APS3v) refers to an autoimmune condition in which both type 1 diabetes (T1D) and autoimmune thyroiditis (AITD) develop in the same individual. HLA-DR3 confers the strongest susceptibility to APS3v. Previously we reported a unique amino acid signature pocket that predisposes to APS3v. We found that this pocket is flexible and can trigger APS3v by presenting both...

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Share to Glutamate Decarboxylase
Share to HLA-DR3 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Humoral

Share to Iodide Peroxidase

Share to Iron-Binding Proteins

Share to Polyendocrinopathies, Autoimmune

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Share to Thyroiditis, Autoimmune

Source

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Identifiers

PMID: 34987519
DOI: 10.3389/fimmu.2021.796552
PMCID: PMC8721038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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