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Article

Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.

The Journal of biological chemistry - 15 Dec 2006

Höpner Sabine, Dickhaut Katharina, Hofstätter Maria, Krämer Heiko, Rückerl Dominik, Söderhäll J Arvid, Gupta Shashank, Marin-Esteban Viviana, Kühne Ronald, Freund Christian, Jung Günther, Falk Kirsten, Rötzschke Olaf

Abstract excerpt

Major histocompatibility complex (MHC) molecules are a key element of the cellular immune response. Encoded by the MHC they are a family of highly polymorphic peptide receptors presenting peptide antigens for the surveillance by T cells. We have shown that certain organic compounds can amplify immune responses by catalyzing the peptide loading of human class II MHC molecules HLA-DR. Here we show now that they...

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PMID: 17005558
DOI: 10.1074/jbc.M606437200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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