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Article

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.

Science (New York, N.Y.) - 21 Apr 2000

Corper A L, Stratmann T, Apostolopoulos V, Scott C A, Garcia K C, Kang A S, Wilson I A, Teyton L

Abstract excerpt

Susceptibility to murine and human insulin-dependent diabetes mellitus correlates strongly with major histocompatibility complex (MHC) class II I-A or HLA-DQ alleles that lack an aspartic acid at position beta57. I-Ag7 lacks this aspartate and is the only class II allele expressed by the nonobese diabetic mouse. The crystal structure of I-Ag7 was determined at 2.6 angstrom resolution as a complex with a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10775108
DOI: 10.1126/science.288.5465.505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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