Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice.

Diabetes - 1 Jan 2012

Bates Holly E, Campbell Jonathan E, Ussher John R, Baggio Laurie L, Maida Adriano, Seino Yutaka, Drucker Daniel J

Abstract excerpt

Glucose-dependent insulinotropic polypeptide (GIP) promotes glucose-dependent insulin secretion. However, GIP also enhances glucocorticoid secretion and promotes adiposity. Because obesity and diabetes are glucocorticoid dependent, we examined whether the effects of GIP on energy balance and glycemia are regulated by glucocorticoids using pharmacological activation of GIP receptor (GIPR) signaling with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Cortex
Share to Adrenal Cortex Hormones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Corticosterone

Share to Diet, High-Fat

Share to Food Deprivation

Share to Glucocorticoids

Share to Metabolism

Share to Steroids

Source

Open in PubMed Open full text

Identifiers

PMID: 22043004
DOI: 10.2337/db11-1060
PMCID: PMC3237652

Genes

GIP
GIPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice.PMID 22043004Read ↗

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout MiceSemantic proximity Read ↗

The beta cell glucocorticoid receptor protects against hyperglycaemia by modulating insulin secretion during glucocorticoid rhythm disruption in miceSemantic proximity Read ↗

Absence of the glucagon-like peptide-1 receptor does not affect the metabolic phenotype of mice with liver-specific G(s)α deficiency.Semantic proximity Read ↗

GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic diseaseSemantic proximity Read ↗

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.Semantic proximity Read ↗

RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient beta-adrenergic signalling in adipocytes from mature C57BL/6J-ob/ob mice.Semantic proximity Read ↗

Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.Semantic proximity Read ↗

Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus.Semantic proximity Read ↗

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variantSemantic proximity Read ↗

Oral Corticosterone Administration Reduces Insulitis but Promotes Insulin Resistance and Hyperglycemia in Male Nonobese Diabetic Mice.Semantic proximity Read ↗

Discovery of Glucocorticoid Receptor-β in Mice with a Role in MetabolismSemantic proximity Read ↗

Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.