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Article

Discovery of Glucocorticoid Receptor-β in Mice with a Role in Metabolism

22 Jul 2010

Abstract excerpt

Glucocorticoid hormones control diverse physiological processes, including metabolism and immunity, by activating the major glucocorticoid receptor (GR) isoform, GRalpha. However, humans express an alternative isoform, human (h)GRbeta, that acts as an inhibitor of hGRalpha to produce a state of glucocorticoid resistance. Indeed, evidence exists that hGRbeta contributes to many diseases and resistance to...

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PMID: 20660300
DOI: 10.1210/me.2009-0411

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