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Article

RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient beta-adrenergic signalling in adipocytes from mature C57BL/6J-ob/ob mice.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Oct 1997

Gettys T W, Watson P M, Taylor I L, Collins S

Abstract excerpt

OBJECTIVE: To investigate the role of hypercorticism in the development of compromised beta-adrenergic signalling in adipocytes of mature C57BL/6J-ob/ob mice. DESIGN AND EXPERIMENTAL UNITS: Mature male ob/ob mice and their lean littermates were treated with vehicle or the specific glucocorticoid receptor (GR) antagonist, RU-486 (30 mg/kg bw/d) for 21 d. MEASUREMENTS: Blood glucose, serum insulin, adipocyte Glut-4...

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Identifiers

PMID: 9347404
DOI: 10.1038/sj.ijo.0800479

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