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Article

RU-486 (Mifepristone) ameliorates diabetes but does not correct deficient beta-adrenergic signalling in adipocytes from mature C57BL/6J-ob/ob mice.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Oct 1997

Gettys T W, Watson P M, Taylor I L, Collins S

Abstract excerpt

OBJECTIVE: To investigate the role of hypercorticism in the development of compromised beta-adrenergic signalling in adipocytes of mature C57BL/6J-ob/ob mice. DESIGN AND EXPERIMENTAL UNITS: Mature male ob/ob mice and their lean littermates were treated with vehicle or the specific glucocorticoid...

Topics

Adenylyl Cyclases
Adipose Tissue
Adrenergic beta-Agonists
Animals
Blood Glucose
Blotting, Northern
Blotting, Western
Colforsin
Diabetes Mellitus, Experimental
Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Activation

Ethanolamines

GTP-Binding Protein alpha Subunits, Gs

Glucose Transporter Type 4

Hormone Antagonists

Insulin

Isoproterenol

Male

Source

Identifiers

PMID: 9347404
DOI: 10.1038/sj.ijo.0800479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9347404-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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