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Article

Plasminogen receptor S100A10 is essential for the migration of tumor-promoting macrophages into tumor sites.

Cancer research - 1 Nov 2011

Phipps Kyle D, Surette Alexi P, O'Connell Paul A, Waisman David M

Abstract excerpt

Macrophages are critical drivers of tumor growth, invasion, and metastasis. Movement of macrophages into tumors requires the activity of cell surface proteases such as plasmin. In this study, we offer genetic evidence that plasminogen receptor S100A10 is essential for recruitment of macrophages to the tumor site. Growth of murine Lewis lung carcinomas or T241 fibrosarcomas was dramatically reduced in...

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PMID: 22042827
DOI: 10.1158/0008-5472.CAN-11-1748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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