Article
Activation of tissue plasminogen activator by metastasis-inducing S100P protein.
The Biochemical journal - 12 Sept 2017
Clarke Christopher J, Gross Stephane R, Ismail Thamir M, Rudland Philip S, Al-Medhtiy Morteta, Santangeli Michael, Barraclough Roger
Abstract excerpt
S100P protein in human breast cancer cells is associated with reduced patient survival and, in a model system of metastasis, it confers a metastatic phenotype upon benign mammary tumour cells. S100P protein possesses a C-terminal lysine residue. Using a multiwell in vitro assay, S100P is now shown for the first time to exhibit a strong, C-terminal lysine-dependent activation of tissue plasminogen activator (tPA),...
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