Article
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP.
The Journal of cell biology - 22 Nov 2004
Sabeh Farideh, Ota Ichiro, Holmbeck Kenn, Birkedal-Hansen Henning, Soloway Paul, Balbin Milagros, Lopez-Otin Carlos, Shapiro Steven, Inada Masaki, Krane Stephen, Allen Edward, Chung Duane, Weiss Stephen J
Abstract excerpt
As cancer cells traverse collagen-rich extracellular matrix (ECM) barriers and intravasate, they adopt a fibroblast-like phenotype and engage undefined proteolytic cascades that mediate invasive activity. Herein, we find that fibroblasts and cancer cells express an indistinguishable pericellular collagenolytic activity that allows them to traverse the ECM. Using fibroblasts isolated from gene-targeted mice, a...
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