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Article

VEGF-A and Tenascin-C produced by S100A4 <sup>+</sup> stromal cells are important for metastatic colonization

12 Sept 2011

Abstract excerpt

Increased numbers of S100A4(+) cells are associated with poor prognosis in patients who have cancer. Although the metastatic capabilities of S100A4(+) cancer cells have been examined, the functional role of S100A4(+) stromal cells in metastasis is largely unknown. To study the contribution of S100A4(+) stromal cells in metastasis, we used transgenic mice that express viral thymidine kinase under control of the...

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PMID: 21911392
DOI: 10.1073/pnas.1109493108

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