Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Class A scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer.

Journal of leukocyte biology - 3 Mar 2026

Monzavi-Karbassi Behjatolah, Kelly Thomas, Jousheghany Fariba, Webber Jessica, Kumarapeli Asangi, Simecka Christy, Alkam Duah, Byrum Stephanie D, Siegel Eric R, Post Steven R

Abstract excerpt

Tumor-associated macrophages (TAMs) are a critical component of the immune response to cancer, and their role in modulating cancer progression is well-recognized. Macrophages express pattern-recognition receptors, including Class A scavenger receptors (SR-A), which are pivotal in regulating macrophage activation and polarization into distinct phenotypes. SR-A expression is generally correlated with altered...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Macrophages

Share to Mammary Neoplasms, Experimental

Share to Membrane Proteins

Share to Scavenger Receptors, Class A

Share to Tumor-Associated Macrophages

Source

Open in PubMed Open full text

Identifiers

PMID: 41749430
DOI: 10.1093/jleuko/qiag026
PMCID: PMC13017966

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Class A scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer.PMID 41749430Read ↗

Scavenger Receptor A1 Prevents Metastasis of Non-Small Cell Lung Cancer via Suppression of Macrophage Serum Amyloid A1.Semantic proximity Read ↗

Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancerSemantic proximity Read ↗

Defining and targeting macrophage heterogeneity in the mammary gland and breast cancerSemantic proximity Read ↗

[Detection and analysis of phenotypes of tumor-associated macrophages in mouse model of spontaneous breast cancer].Semantic proximity Read ↗

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and MetastasisSemantic proximity Read ↗

The cellular and molecular origin of tumor-associated macrophagesSemantic proximity Read ↗

Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes.Semantic proximity Read ↗

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cellsSemantic proximity Read ↗

Plasminogen receptor S100A10 is essential for the migration of tumor-promoting macrophages into tumor sites.Semantic proximity Read ↗

Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.Semantic proximity Read ↗

Unique macrophage phenotypes activated by BMP signaling in breast cancer bone metastases.Semantic proximity Read ↗

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.