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SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages

27 Aug 2019

Abstract excerpt

Abstract SerpinB2 (plasminogen activator inhibitor type 2) has been called the “undecided serpin” with no clear consensus on its physiological role, although it is well described as an inhibitor of urokinase plasminogen activator (uPA). In macrophages, pro-inflammatory stimuli usually induce SerpinB2; however, expression is constitutive in Gata6+ large peritoneal macrophages (LPM). Interrogation of expression...

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PMID: 31455834
DOI: 10.1038/s41598-019-48741-w

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