Article
Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.
Nature communications - 2 Feb 2022
Borriello Lucia, Coste Anouchka, Traub Brian, Sharma Ved P, Karagiannis George S, Lin Yu, Wang Yarong, Ye Xianjun, Duran Camille L, Chen Xiaoming, Friedman Madeline, Sosa Maria Soledad, Sun Dan, Dalla Erica, Singh Deepak K, Oktay Maja H, Aguirre-Ghiso Julio A, Condeelis John S, Entenberg David
Abstract excerpt
Metastases are initiated by disseminated tumor cells (DTCs) that colonize distant organs. Growing evidence suggests that the microenvironment of the primary tumor primes DTCs for dormant or proliferative fates. However, the manner in which this occurs remains poorly understood. Here, using the Window for High-Resolution Intravital Imaging of the Lung (WHRIL), we study the live lung longitudinally and follow the...
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