Article
The selection of acceptable protein mutations.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2007
Sasidharan Rajkumar, Chothia Cyrus
Abstract excerpt
We have determined the general constraints that govern sequence divergence in proteins that retain entirely, or very largely, the same structure and function. To do this we collected data from three different groups of orthologous sequences: those found in humans and mice, in humans and chickens, and in Escherichia coli and Salmonella enterica. In total, these organisms have 21,738 suitable pairs of orthologs,...
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